Neuropharmacology '85 [antikvár]

PREFACE This volume is dedicated to Professor Joseph Knoll on the occasion of his 60th birthday. Dr. Knoll is a graduate of the Budapest University Medicai School (now the Semmelweis University of Medicine) . He has been working in the Department of Pharmacology since finishing his university studies and was appointed professor and department head in 1962. The broad range of his scientific activity and his originai thinking have made his scientific endeavours extremely fruitful. He is not only outstanding in the area of scientific theories, but he also excels at applying them in practice. He has devoted himself to extensive research in neuro- and psychopharmacology, a field in which he has developed numerous techniques and new Compounds which won him International fame. He has developed the first selective monoamine oxidase inhibitor, deprenyl (Jumex, Elderpyl) which became a drug used world-wide as the prototype of the selective inhibitors of the B type of MAO and is registered in a number of countries as an adjuvant in the therapy of Parkinson's disease. He has worked out a new group of non-narcotic analgésies (homopyrimidazols) with special spectrum of activity (one mem-ber of this group, Probon, is a registered drug in Hungary and in many other countries) and a new family of semisynthetic morphine derivatives, (azidomorphines), with remarkably low tolerance and dependence capacities. Using N-substituted noraz-idomorphines as new tools, he succeeded in discriminating