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Coauthored by three of the world's foremost authorities--all directors of the International Cerebral Blood Flow and Metabolism Society--this landmark work is the only current comprehensive text and reference on cerebral blood flow and metabolism. Unlike other books, which focus on a single aspect of cell metabolism or the cerebral circulation, this volume covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. The value of the book is further enhanced by the authors' stimulating discussions of future directions for research and therapeutic intervention.