Clarke's Isolation and Identification of Drugs [antikvár]

PrefaceIsolation and Identification of Drugs was first published in 1969 from an idea developed by Professor E. G. C. Clarke, who edited that first edition. Regrettably, Professor Clarke did not live to see the inception of a new edition. It seemed fitting, therefore, to call this new edition Clarke's Isolation and Identification of Drugs, especially as the book is affectionately known as 'Clarke'. The first edition became a standard reference text for those concerned with the identification of drugs, gaining its reputation by providing a dependable source of analytical data for drugs and allied substances. The dog-eared, stained copies on laboratory benches are a testament to its usefulness. Accidental or suicidal poisoning, the abuse of narcotics and other drugs, the dangerous habit of glue-sniffing, and drug abuse in sport have increased enormously during recent years. The information in this book has been planned to provide the means for detecting, identifying, and quantifying most drugs and other toxic substances which are likely to be encountered in these situations, and to assist in interpreting the analytical results. The book was planned for use not only in hospital and toxicological laboratories, but also in numerous other analytical establishmentsincluding hospital and industrial quality control laboratories, and chnical laboratories engaged in drug investigations for purposes such as therapeutic drug monitoring or research into pharmacokinetics and patterns of drug metabolism. Also, there is much information which will be of use in certain areas of environmental toxicology, particularly the analysis of toxic metals and pesticides. Finally, the needs of students who are studying drug analysis and its applications have been kept in mind during the writing of the book.There have been many developments in analytical techniques since the first edition was published, and this has necessitated rewriting the whole of the text and the inclusion of new data throughout. Nevertheless, the style and presentation used in the first edition have been retained. The amount of text in the book has been increased by about 60% which has been made possible by increasing the page size and using a double column format throughout. Whenever possible, the datahave been verified from at least one independent source.The book is divided into four parts.Part 1: Analytical Techniques This part contains 18 chapters on analytical techniques and allied subjects. New chapters in this edition include descriptions of hospital toxicology and drug abuse screening, forensic toxicology, drug abuse in sport, therapeutic drug monitoring, the analysis of metals and anions, and the analysis of pesticides, together with information on sampling procedures and on the use of quality control in clinical analysis.The information on analytical techniques has been extended and brought up to date, particularly with the inclusion of high pressure liquid chromatography, fluorescence spectrophotometry, and nuclear magnetic resonance spectroscopy. Each chapter provides a description of the technique, practical hints on its use, and information on the application of the technique to problems. The chromatographic systems have been completely revised and made more comprehensive and systematic. The general screening system using thin-layer chromatography has been extended and, for the first time, general screening systems employing gas chromatography and high pressure liquid chromatography are described. The information on colour tests has been completely revised and extended. The older methods of paper chromatography and microcrystalline tests have been omitted from this edition. A final chapter brings together the knowledge of pharmacokinetics and drug metabolism which is needed for the interpretation of the qualitative and quantitative results obtained from the analyses.Part 2: Analytical and Toxicological Data This part contains monographs for over 1300 drugs and related substances. About 160 substances which were included in the first edition, but which are now of little interest, have been deleted (see p. xvii). However, about 300 substances not described previously have been added. A new feature of this edition is the inclusion of ultraviolet spectra. These, together with infra-red