Estrogen-Induced Tumors of the Kidney in the Syrian Hamster [antikvár]

Estrogen-lnduced Tumors of the Kidney. III. Growth Characteristics in the Syrian Hamster1-3 Hadley Kirkman,4 Department of Anatomy, Stanford University School of Medieine, Stanford, California, and the Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospitál, London, England SUMMARY The induction, latent period, growth rate, prevention, regression and viability, transplantation, and dependency versus autonoray of an estrogen-induced malignant, metastasizing renal neoplasm in the Syrian hamster are deseribed and discussed. Investigation of these phenomena included: various hormones in addition to estrogens, e.g., testosterone propionate, progesterone, deoxycorticosterone acetate, cortisone, and ACTH; and various surgical procedures, e.g., gonadectomy, adrenalectomy, hypophysectomy, renal traumatization, and unilateral nephrectomy. The possible meehanism of estrogen tumorigenesis is discussed and the value of the hormonally induced renal carcinoma is emphasized, particularly in studies of carcinogenesis. A KIDNEY tumor in an estrogen-treated Syrian hamster (Mesocricetus auratus, formerly Cricetus auratus) was first mentioned by VasquezLopez (1), who regarded it as a metastasis from the estrogen-induced, pars intermedia, pituitary-gland tumor first deseribed by him. There can be no serious doubt, however, that his "large, secondary deposit macroscopically visible in the left kidney" was a primary renal neoplasm such as that deseribed originally by Matthews, Kirkman, and Bacon (2) and later, in more detail, by Kirkman and Bacon (3-5), Horning (6-8), Horning and Whittick (9), Kirkman (10-12), and others. At first these neoplasms were induced only in males and in gonadectomized hamsters of both sexes. Later (10, 11, 13) it was demonstrated that they alsó could be induced in 1 Received for publication December 29, 1958; revised May 25, 1959. ' This investigation was supported in part by research grants from the American Cancer Society, Inc., the National Cancer Institute, National Institutes of Health, Public Health Service, and the Jane Coffin Childs Memóriái Fund for Medical Research. ' The experimentál work reported here was complcted at Stanford University; the data were assembled and the manuseript prepared during the author's tenure of a Senior National Science Foundation Fellowship (1957- 58) and a Special U.S. Public Health Service Fellowship (1958-59) at the Chester Beatty Research Institute. 41 wisb to thank the National Science Foundation, the Public Health Service, and the Chester Beatty Research Institute for making this study possible. My special thanks to Professor Erié Horning for numerous stimulating discussions and for reading the manuseript. The technical assistance of Drs. Masako A. Baba, Elizabeth M. Center, Mariano Obias, Róbert Squire, and Sydney F. Thomas and of Fay Agate, Frank Barrett, Ray Crabbe, Gladys T. Kirkman, Max Millsap, Lee Nicholas, Yoshio Okumoto, and Marilyn Robbins, of Stanford University, and Michael J. Docherty, Róbert McCullock, Kenneth Moreman, and Edward A. Sykes, of the Chester Beatty Research Institute, is gratefully acknowledged. Diethylstilbestrol and various hormones were generously supplied by the Ciba Pharmaceutical Products, Inc., Summit, N. J.