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PrefaceCertainty is everywhere, fundamentalism is in full bloom. Legions of authorities cloaked in total conviction tell us why we should invade country X, ban The Adventures of Huckleberry Finn in schools, or eat stewed tomatoes; how much brain damage is necessary to justify a plea of diminished capacity; the precise moment when a sperm and an egg must be treated as a human being; and why the stock market will eventually revert to historical returns. A public change of mind is national news.But why? Is this simply a matter of stubbornness, arrogance, and/or misguided thinking, or is the problem more deeply rooted in brain biology? Since my early days in neurology training, I have been puzzled by this most basic of cognitive problems: What does it mean to be convinced? At first glance, this question might sound foolish. You study the evidence, weigh the pros and cons, and make a decision. If the evidence is strong enough, you are convinced that there is no other reasonable answer. Your resulting