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INTRODUCTIONGo outside and play in the sun. It's good for you.My motherThe use of sunlight and drugs for the treatment of skin diseases has been documented for over 3400 years; for an even longer time, the reddening, blistering, and tanning effects of sunlight have probably been known. With the discovery of lasers a new dimension was added in the study and application of light in medical therapy. Ophthalmologists adopted the laser in the clinic as a photocoagulator for the treatment of detached retina, and the use of laser as a scalpel for noncontact, noninvasive, and even subcellular surgery is at an earlier state of acceptance. In addition to surgical uses, new, promising ideas are continuing to emerge. Thus, laser can be used to diagnose and treat malignant tumors using photoradiation therapy. This renewed interest, stimulated by the mutual interplay of both scientific and technological innovations, is characterized by a multidisciplinary approach involving physicists, chemists, biochemists, and physicians.Our objective has been to collect in these three volumes the most up-to-date assessment of our understanding of light in medicine. Since Photomedicine was defined as an informative guide to practical applications rather than an esoteric study of medical discipline, the level of medical rigor was reasonably relaxed.Given limitations on length, the chapters are not intended to be all embracing reviews of the field, but rather to present an overview of key ideas and directions with the objective of delineating the most promising and exciting problems. We hope that the text is sufficiently introductory to stimulate the curiosity and interest of a neophyte, and to simultaneously provide the specialist with a rather short, but current summary of the status of this field. Most important, we hope that the volumes will further highlight this rapidly developing science and spur current and new researchers and ideas.Ehud Ben-Hur lonel RosenthalINTRODUCTIONGo outside and play in the sun. It's good for you.My motherThe use of sunlight and drugs for the treatment of skin diseases has been documented for over 3400 years; for an even longer time, the reddening, blistering, and tanning effects of sunlight have probably been known. With the discovery of lasers a new dimension was added in the study and application of light in medical therapy. Ophthalmologists adopted the laser in the clinic as a photocoagulator for the treatment of detached retina, and the use of laser as a scalpel for noncontact, noninvasive, and even subcellular surgery is at an earlier state of acceptance. In addition to surgical uses, new, promising ideas are continuing to emerge. Thus, laser can be used to diagnose and treat malignant tumors using photoradiation therapy. This renewed interest, stimulated by the mutual interplay of both scientific and technological innovations, is characterized by a multidisciplinary approach involving physicists, chemists, biochemists, and physicians.Our objective has been to collect in these three volumes the most up-to-date assessment of our understanding of light in medicine. Since Photomedicine was defined as an informative guide to practical applications rather than an esoteric study of medical discipline, the level of medical rigor was reasonably relaxed.Given limitations on length, the chapters are not intended to be all embracing reviews of the field, but rather to present an overview of key ideas and directions with the objective of delineating the most promising and exciting problems. We hope that the text is sufficiently introductory to stimulate the curiosity and interest of a neophyte, and to simultaneously provide the speciaHst with a rather short, but current summary of the status of this field. Most important, we hope that the volumes will further highlight this rapidly developing science and spur current and new researchers and ideas.Ehud Ben-Hur lonel RosenthalINTRODUCTIONGo outside and play in the sun. It's good for you.My motherThe use of sunlight and drugs for the treatment of skin diseases has been documented for over 3400 years; for an even longer time, the reddening, blistering, and tanning effects of sunlight have probably been known. With the discovery of lasers a new dimension was added in the study and application of light in medical therapy. Ophthalmologists adopted the laser in the clinic as a photocoagulator for the treatment of detached retina, and the use of laser as a scalpel for noncontact, noninvasive, and even subcellular surgery is at an earlier state of acceptance. In addition to surgical uses, new, promising ideas are continuing to emerge. Thus, laser can be used to diagnose and treat malignant tumors using photoradiation therapy. This renewed interest, stimulated by the mutual interplay of both scientific and technological innovations, is characterized by a multidisciplinary approach involving physicists, chemists, biochemists, and physicians.Our objective has been to collect in these three volumes the most up-to-date assessment of our understanding of light in medicine. Since Photomedicine was defined as an informative guide to practical applications rather than an esoteric study of medical discipline, the level of medical rigor was reasonably relaxed.Given limitations on length, the chapters are not intended to be all embracing reviews of the field, but rather to present an overview of key ideas and directions with the objective of delineating the most promising and exciting problems. We hope that the text is sufficiently introductory to stimulate the curiosity and interest of a neophyte, and to simultaneously provide the specialist with a rather short, but current summary of the status of this field. Most important, we hope that the volumes will further highlight this rapidly developing science and spur current and new researchers and ideas.Ehud Ben-Hur lonel Rosenthal