Recent Progress in Perinatal Medicine IV. [antikvár]

the application of dimethyl sulfoxide in obstetrical and gynaecological practice P.Ya. Kintraya, I.D. Mamamtavrishvili, Sh.Sh. Kherodinashvili Academician Chachava Scientific Research Institute of Perinatal Medicine, Obstetrics and Gynaecology, Public Health, Georgian SSR, Tbilissi, USSR The prenatal fetal defence against the consequences of hypoxia and intracranial birth trauma is a main problem of modem perinatology. The prevention and treatment of these complications in labor are being realized by medicamentous influence on the maternal organism. The means applied for this purpose affect the fetus only in an indirect way, and many of them passing through natural biological barriers get to the destination in unsufficient effective concentrations. That's why finding of the possibility of the indirect effect of these medicamental drugs on the fetus in the labor process, in our opinion, in the most perspective. The aim of our investigations was to study wether it is possible to use dimethyl sulfoxide (DMSO) as a carrier of medical drugs for the treatment of the consequences of fetal cerebral oxygenous deficiency. As long ago as 1964 there appeared literary data on the application of DMSO as a drug carrier and at the same time as a preparation with merked physiologic effect (1). Its biological activity is based on its absolute solvent power which enables DMSO to pass through all the biological barriers, penetrate the cells transporting molecules of drug agents. Competing with water for the hydrogenous bindings, the preparation is capable to „reject" water, connect with protein, changing its configuration and abilities. DMSO easily penetrates through the undamaged skin, carrying dissolved preparations which significantly accumulate in blood. Thus, according to the data (2), diffusion of sulfanilamide and aspirin from pointments with DMSO increased 4 times as large as compared with the control. Decrease of intracranial pressure, edema and cerebral inschemia, caused by DMSO can be accounted for the membrane dehydration and alteration of the ionic transport (3, 4). One of the most interesting phenomena of the preparation effect is the opening of the brain - blood barrier for the penetration of high - molecular bindings and proteins which is hot accompanied by the alteration of endothelial cells and cerebral parenchyma (5). Recently there appeared some data on testifying to the fact that DMSO administration prevents cells against hypoxic damages; particularly it prevents mitochondria agaist the disturbance of oxidative phosphory-lated processes (6, 7). The primary task of our investigation was to define the optimum,