Suprecur - A Caring Approach to Endometriosis [antikvár]

Introduction Since Schally and Guillemin introduced synthetic LHRH in 1971, there have been many studies of the mode of action of this hypothalamic hormone and the feedback mechanisms between hypothalamus, pituitary and gonads. LHRH stimulates the release and the synthesis of the gonadotropins, LH and FSH, which in turn stimulate gonadal steroidogenesis (Fig. 1) (1,3,4,5). Studies of the binding sites of gonadal LH receptors and of pituitary LHRH receptors have been particularly important (2). Prolonged LHRH stimulation first increases, then reduces receptor numbers, so that gonadotropin and gonadal steroid levels are eventually suppressed. Decisive in determining the receptor loss are the dose and the dose interval of LHRH treatment. The suppression is completely reversible.